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Lactic acidosis is a medical emergency and must be treated in the hospital.

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Kombiglyze xr 5 1000 mg uses. Important Safety Information Important Safety Information. KOMBIGLYZE XR can cause serious side effects, including lactic acidosis. KOMBIGLYZE XR is a prescription medicine that contains saxagliptin and metformin hydrochloride.

KOMBIGLYZE XR is used with diet and exercise to help control high blood sugar (hyperglycemia) in adults with type 2 diabetes. Your doctor will decide if treatment with both saxagliptin and metformin is right for you. Metformin, one of the medicines in KOMBIGLYZE XR, can cause a rare, but serious, condition called lactic acidosis (a build-up of an acid in the blood) that can cause death.

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